tag:blogger.com,1999:blog-2301999496344158780.post1936164170118671251..comments2023-10-02T04:54:51.199-07:00Comments on The MacGuffin: Valdoxan: The Ideal Anti-Depressant Part 1NeuroPsychhttp://www.blogger.com/profile/10654138293659468787noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-2301999496344158780.post-69268419642846830232012-11-02T23:29:58.954-07:002012-11-02T23:29:58.954-07:00Ive just read part 1. I sense an effect directly a...Ive just read part 1. I sense an effect directly after taking Prozac but not other SSRIs. I am sure it's the HT-2c antagonism which in turn increases dopamine and noradrenaline in frontal cortex. When the Serotinergic effects poop in one just gets numbed down. However it's supposely the combination of M1 and M2 agonism combined with HT-2c antagonism which makes it work (probably for those with hypofrontality). I noticed a comment above saying if NA/DA is the problem use Ritalin. Well I can tell you that gives me a really good respond I even start to play piano which I've procrastinated for years. But however I wont get them prescribed and it seems tolerance is very common. Another alternative for a "general" increase in Dopamin And noradrenaline Reuptake inhibitation would be Wellbutrin. As with Agomelatine I dont think just an HT-2c antagonism would be enough or if it's a HT-2c inverted agonism which I assume means the blockade will be stronger the more Hydrotryptofan which is projected at those receptors. I am unsure of that point. However, I think if problem is Anhedonia, hypofrontalism (lack of ability to withstand stimuli and/or reacting a long time afterwards), I think agomelatine might be of use. Hypofrontalism seems to be the key however and there's a lot of differential diagnosis when it comes to it. /MartyAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-20884631394487587342012-01-28T13:23:32.158-08:002012-01-28T13:23:32.158-08:00I've been taking 25mg of agomelatine for two w...I've been taking 25mg of agomelatine for two weeks now. Amazing, no side effects at all. I'm normally very sensitive to antidepressants as 10mg of Prozac gave me NLS /EPS side effects!<br /><br />Very subtle effects. Does help with sleep but still wake up. Just get back to sleep quicker.<br /><br />Doesn't feel like a stimulant at all. I have taken Modafinil in the past and it is not as activating as this. Also have taken Zyban in the past as not as activating as Zyban.<br /><br />Agomelatine seems to reduce impulsiveness, anxiety and excessive rumination and imrpove concentration. It seems to have modest antidepressant properties although can feel this effect wear off by lunchtime. Might take 25mg before bed and 25mg at lunchtime.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-9880057863646214642011-08-06T15:39:14.747-07:002011-08-06T15:39:14.747-07:00I have been taking Valdoxan 25mg for two months. I...I have been taking Valdoxan 25mg for two months. It has done very little for my mild depression. Worsened the quality of my sleep, caused anorgasmia and elevated liver enzymes. My pdoc said he will stop prescribing it to his patients. In his opinion over-the-counter melatonin is as effective, cheaper and more gentle to the liver. I'll go back to Wellbutrin. Please note that a recent study by a French agency lists Valdoxan as one of the eight more dangerous drugs sold in France.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-72271264253116366892010-04-02T04:12:57.770-07:002010-04-02T04:12:57.770-07:00I liked agomelatine and its definitely working.
Th...I liked agomelatine and its definitely working.<br />Though there is a bad side effect namely horrible stomach pains and gas and gastritis.This side effect is actually worse then with SSRI's although the company still denies it.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-55546389105220310622010-02-16T13:55:04.427-08:002010-02-16T13:55:04.427-08:00Been on Agomelatine for quite some time now (going...Been on Agomelatine for quite some time now (going on 1 year +), it has been a good med w/ a very low side effect profile. Still fiddling w/ the dose 25 to 50mg. I would say it has moderate efficacy with excellent mood-stabilizing effect the side effect profile has been almost unnoticeable. This should provide psychiatrists with more tools for the many ppl who cannot tolerate SSRI's due to their horrid side effect profile. Agomelatine has been worth every penny I've spent on it so far.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-24715224531986681942009-12-23T13:40:45.798-08:002009-12-23T13:40:45.798-08:00I have been prescribed Agomelatine and have been d...I have been prescribed Agomelatine and have been docucmenting my side effects etc on my blog. Crashing into the Mental SystemAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-63498570009159710262009-11-24T15:43:23.466-08:002009-11-24T15:43:23.466-08:00All anti-depressants have pretty lengthy half-live...All anti-depressants have pretty lengthy half-lives (minus paroxetine)...and venlafaxine?....https://www.blogger.com/profile/08461338194309128443noreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-59913529427349223372009-11-19T05:28:43.670-08:002009-11-19T05:28:43.670-08:00I've seen rat data that agomelatine acutely bo...I've seen rat data that agomelatine acutely boosts cortical NA/DA levels, presumably via 5HT2C blockade... but as the person presenting that data said, whether this will persist into the next day is another matter.<br /><br />Plus if you wanted to boost NA/DA levels, you would give someone Ritalin. Somehow I don't think agomelatine works like that.Neuroskeptichttps://www.blogger.com/profile/06647064768789308157noreply@blogger.comtag:blogger.com,1999:blog-2301999496344158780.post-10379867502309244812009-10-28T00:30:49.681-07:002009-10-28T00:30:49.681-07:00Great! You made the "mechanism" part whi...Great! You made the "mechanism" part which I was not able to do properly in my german <a href="http://www.adfd.org/wissen/Agomelatin" rel="nofollow">Agomelatine Efficacy/Risk Review</a>. I'm looking forward, cannot wait for pt 2.<br /><br />By the way, the "Bigger than Prozac" fake study got my comment over on <a href="http://www.furiousseasons.com/archives/2009/09/bigger_than_prozac.html" rel="nofollow">Furious Seasons</a>.<br /><br />Keep up the good work!PhilRShttp://www.adfd.org/noreply@blogger.com